Real clocks and the Zeno effect

Real clocks are not perfect. This must have an effect in our predictions for the behaviour of a quantum system, an effect for which we present a unified description encompassing several previous proposals. We study the relevance of clock errors in the Zeno effect, and find that generically no Zeno effect can be present (in such a way that there is no contradiction with currently available experimental data). We further observe that, within the class of stochasticities in time addressed here, there is no modification in emission lineshapes.Comment: 12 a4 pages, no figure

Analysis of Ωc∗(css)\Omega_c^*(css) and Ωb∗(bss)\Omega_b^*(bss) with QCD sum rules

In this article, we calculate the masses and residues of the heavy baryons $\Omega_c^*(css)$ and $\Omega_b^*(bss)$ with spin-parity ${3/2}^+$ with the QCD sum rules. The numerical values are compatible with experimental data and other theoretical estimations.Comment: 13 pages, 8 figures, slight versio

Identifying diachronic topic-based research communities by clustering shared research trajectories

Communities of academic authors are usually identified by means of standard community detection algorithms, which exploit ‘static’ relations, such as co-authorship or citation networks. In contrast with these approaches, here we focus on diachronic topic-based communities –i.e., communities of people who appear to work on semantically related topics at the same time. These communities are interesting because their analysis allows us to make sense of the dynamics of the research world –e.g., migration of researchers from one topic to another, new communities being spawn by older ones, communities splitting, merging, ceasing to exist, etc. To this purpose, we are interested in developing clustering methods that are able to handle correctly the dynamic aspects of topic-based community formation, prioritizing the relationship between researchers who appear to follow the same research trajectories. We thus present a novel approach called Temporal Semantic Topic-Based Clustering (TST), which exploits a novel metric for clustering researchers according to their research trajectories, defined as distributions of semantic topics over time. The approach has been evaluated through an empirical study involving 25 experts from the Semantic Web and Human-Computer Interaction areas. The evaluation shows that TST exhibits a performance comparable to the one achieved by human experts

Light-cone QCD Sum Rules for the Λ\Lambda Baryon Electromagnetic Form Factors and its magnetic moment

We present the light-cone QCD sum rules up to twist 6 for the electromagnetic form factors of the $\Lambda$ baryon. To estimate the magnetic moment of the baryon, the magnetic form factor is fitted by the dipole formula. The numerical value of our estimation is $\mu_\Lambda=-(0.64\pm0.04)\mu_N$, which is in accordance with the experimental data and the existing theoretical results. We find that it is twist 4 but not the leading twist distribution amplitudes that dominate the results.Comment: 13 page, 7 figures, accepted for publication in Euro. Phys. J.

Automated Coronal Hole Detection using Local Intensity Thresholding Techniques

We identify coronal holes using a histogram-based intensity thresholding technique and compare their properties to fast solar wind streams at three different points in the heliosphere. The thresholding technique was tested on EUV and X-ray images obtained using instruments onboard STEREO, SOHO and Hinode. The full-disk images were transformed into Lambert equal-area projection maps and partitioned into a series of overlapping sub-images from which local histograms were extracted. The histograms were used to determine the threshold for the low intensity regions, which were then classified as coronal holes or filaments using magnetograms from the SOHO/MDI. For all three instruments, the local thresholding algorithm was found to successfully determine coronal hole boundaries in a consistent manner. Coronal hole properties extracted using the segmentation algorithm were then compared with in situ measurements of the solar wind at 1 AU from ACE and STEREO. Our results indicate that flux tubes rooted in coronal holes expand super-radially within 1 AU and that larger (smaller) coronal holes result in longer (shorter) duration high-speed solar wind streams

A hybrid semantic approach to building dynamic maps of research communities

In the last ten years, ontology-based recommender systems have been shown to be effective tools for predicting user preferences and suggesting items. There are however some issues associated with the ontologies adopted by these approaches, such as: 1) their crafting is not a cheap process, being time consuming and calling for specialist expertise; 2) they may not represent accurately the viewpoint of the targeted user community; 3) they tend to provide rather static models, which fail to keep track of evolving user perspectives. To address these issues, we propose Klink UM, an approach for extracting emergent semantics from user feedbacks, with the aim of tailoring the ontology to the users and improving the recommendations accuracy. Klink UM uses statistical and machine learning techniques for finding hierarchical and similarity relationships between keywords associated with rated items and can be used for: 1) building a conceptual taxonomy from scratch, 2) enriching and correcting an existing ontology, 3) providing a numerical estimate of the intensity of semantic relationships according to the users. The evaluation shows that Klink UM performs well with respect to handcrafted ontologies and can significantly increase the accuracy of suggestions in content-based recommender systems

Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET

A bispecific antibody (BsAb) targeting the epidermal growth factor receptor (EGFR) and mesenchymal-epithelial transition factor (MET) pathways represents a novel approach to overcome resistance to targeted therapies in patients with nonsmall cell lung cancer. In this study, we sequentially screened a panel of BsAbs in a combinatorial approach to select the optimal bispecific molecule. The BsAbs were derived from different EGFR and MET parental monoclonal antibodies. Initially, molecules were screened for EGFR and MET binding on tumor cell lines and lack of agonistic activity toward MET. Hits were identified and further screened based on their potential to induce untoward cell proliferation and crossphosphorylation of EGFR by MET via receptor colocalization in the absence of ligand. After the final step, we selected the EGFR and MET arms for the lead BsAb and added low fucose Fc engineering to generate amivantamab (JNJ-61186372). The crystal structure of the anti-MET Fab of amivantamab bound to MET was solved, and the interaction between the two molecules in atomic details was elucidated. Amivantamab antagonized the hepatocyte growth factor (HGF)-induced signaling by binding to MET Sema domain and thereby blocking HGF beta-chain-Sema engagement. The amivantamab EGFR epitope was mapped to EGFR domain III and residues K443, K465, I467, and S468. Furthermore, amivantamab showed superior antitumor activity over small molecule EGFR and MET inhibitors in the HCC827-HGF in vivo model. Based on its unique mode of action, amivantamab may provide benefit to patients with malignancies associated with aberrant EGFR and MET signaling.Transplantation and autoimmunit

Hamiltonian Theory of the FQHE: Conserving Approximation for Incompressible Fractions

A microscopic Hamiltonian theory of the FQHE developed by Shankar and the present author based on the fermionic Chern-Simons approach has recently been quite successful in calculating gaps and finite tempertature properties in Fractional Quantum Hall states. Initially proposed as a small-$q$ theory, it was subsequently extended by Shankar to form an algebraically consistent theory for all $q$ in the lowest Landau level. Such a theory is amenable to a conserving approximation in which the constraints have vanishing correlators and decouple from physical response functions. Properties of the incompressible fractions are explored in this conserving approximation, including the magnetoexciton dispersions and the evolution of the small-$q$ structure factor as \nu\to\half. Finally, a formalism capable of dealing with a nonuniform ground state charge density is developed and used to show how the correct fractional value of the quasiparticle charge emerges from the theory.Comment: 15 pages, 2 eps figure

Hamiltonian Description of Composite Fermions: Magnetoexciton Dispersions

A microscopic Hamiltonian theory of the FQHE, developed by Shankar and myself based on the fermionic Chern-Simons approach, has recently been quite successful in calculating gaps in Fractional Quantum Hall states, and in predicting approximate scaling relations between the gaps of different fractions. I now apply this formalism towards computing magnetoexciton dispersions (including spin-flip dispersions) in the $\nu=1/3$, 2/5, and 3/7 gapped fractions, and find approximate agreement with numerical results. I also analyse the evolution of these dispersions with increasing sample thickness, modelled by a potential soft at high momenta. New results are obtained for instabilities as a function of thickness for 2/5 and 3/7, and it is shown that the spin-polarized 2/5 state, in contrast to the spin-polarized 1/3 state, cannot be described as a simple quantum ferromagnet.Comment: 18 pages, 18 encapsulated ps figure

Heavy Quarks and Heavy Quarkonia as Tests of Thermalization

We present here a brief summary of new results on heavy quarks and heavy quarkonia from the PHENIX experiment as presented at the "Quark Gluon Plasma Thermalization" Workshop in Vienna, Austria in August 2005, directly following the International Quark Matter Conference in Hungary.Comment: 8 pages, 5 figures, Quark Gluon Plasma Thermalization Workshop (Vienna August 2005) Proceeding